- Messages
- 138
- Reaction score
- 13
- Points
- 18
⠀
PE-22-28 is a synthetic peptide fragment derived from the naturally occurring protein adrenocorticotropic hormone (ACTH). Its special feature is its ability to influence neurogenesis, mood regulation, and stress resilience without the hormonal effects of ACTH itself.
Mechanism in research:
• Acts on melanocortin and neurotrophic pathways, promoting neuronal growth and protection
• Enhances BDNF (Brain-Derived Neurotrophic Factor) expression, supporting cognitive and emotional balance
• May reduce anxiety-like responses in animal models
• Helps stabilize hypothalamic-pituitary-adrenal (HPA) axis activity under stress
• Exhibits neuroprotective effects in models of aging and neurodegeneration
Main effects (in studies):
• Supports neurogenesis and neuron survival
• Promotes stress adaptation and emotional stability
• Enhances cognitive performance under fatigue
• Reduces markers of oxidative and cellular stress
• Improves motivation and mental focus in behavioral research
Research uses:
• Neuroprotection studies — investigating brain resilience and aging
• Mood and stress research — models of anxiety or emotional regulation
• Cognitive enhancement in fatigue or sleep-deprivation studies
• Neural recovery protocols, often in combination with BDNF-stimulating compounds
• Exploratory research on motivation and focus modulation
Key takeaway:
PE-22-28 is being studied for its neurogenic and mood-balancing effects, offering insight into how peptides can support brain health, resilience, and motivation without hormonal influence.
For educational and research purposes only. Not intended as personal guidance or medical advice.
PE-22-28 is a synthetic peptide fragment derived from the naturally occurring protein adrenocorticotropic hormone (ACTH). Its special feature is its ability to influence neurogenesis, mood regulation, and stress resilience without the hormonal effects of ACTH itself.
Mechanism in research:• Acts on melanocortin and neurotrophic pathways, promoting neuronal growth and protection
• Enhances BDNF (Brain-Derived Neurotrophic Factor) expression, supporting cognitive and emotional balance
• May reduce anxiety-like responses in animal models
• Helps stabilize hypothalamic-pituitary-adrenal (HPA) axis activity under stress
• Exhibits neuroprotective effects in models of aging and neurodegeneration
Main effects (in studies):
• Supports neurogenesis and neuron survival
• Promotes stress adaptation and emotional stability
• Enhances cognitive performance under fatigue
• Reduces markers of oxidative and cellular stress
• Improves motivation and mental focus in behavioral research
Research uses:• Neuroprotection studies — investigating brain resilience and aging
• Mood and stress research — models of anxiety or emotional regulation
• Cognitive enhancement in fatigue or sleep-deprivation studies
• Neural recovery protocols, often in combination with BDNF-stimulating compounds
• Exploratory research on motivation and focus modulation
Key takeaway:PE-22-28 is being studied for its neurogenic and mood-balancing effects, offering insight into how peptides can support brain health, resilience, and motivation without hormonal influence.
For educational and research purposes only. Not intended as personal guidance or medical advice.