🧬 SLUPPY aka SLU-PP-332 Is the Cheat-Code Turning Treadmills Into Relics

[aimanabolic]

 

[aimanabolic]

CARDIO vs “SLUPPY” (SLU-PP-332) — Do You Really Have to Choose? ​

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What We’re Talking About
• Cardio – the traditional route for improving metabolic health, work capacity, and fat loss.
• SLU-PP-332 (nicknames you’ll hear: Sluppy, Slurp-Three, S-332) – a first-in-class PPARδ / REV-ERBβ agonist that ramps up fat oxidation, raises VO₂ max, and sparks “exercise-mimetic” gene pathways.

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Is SLU-PP-332 a Replacement or a Supplement?
• Replacement? Not really. Cardio still delivers cardiovascular remodeling, skill practice (e.g., running form), and mental benefits that a molecule can’t 100 % copy.
• Supplement? Absolutely. Think of SLU-PP-332 as smart cardio insurance: it keeps mitochondrial biogenesis humming when you’re deloading, traveling, or nursing an injury.

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When & How to Deploy It
1. Cut Phases: Use SLU-PP-332 alongside a calorie deficit to hold onto strength while burning fat.
2. Recomp / “Busy-Life” Blocks: Too slammed for daily cardio? A low-impact stack with SLU-PP-332 can preserve endurance markers in half the time.
3. Contest Prep Peak-Weeks: Maintain oxidative capacity without piling on additional systemic fatigue from extra steady-state work.
4. Injury Rehab: Keep VO₂-related enzymes elevated while joints, soft tissue, or tendons heal.
5. Endurance Athletes: Layer it on top of aerobic training blocks to push ceilings higher (careful to respect anti-doping rules!).

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Injection vs Oral Delivery
• Oil-Based IM (Intramuscular) Injections
 – Pros: Near-100 % bioavailability, bypasses first-pass liver metabolism, no GI upset.
 – Cons: Possible mild PIP (post-injection pain) unless using a high-quality carrier oil; requires sterile technique.
• Oral / Sublingual Suspensions
 – Pros: Zero needles, easier titration during travel.
 – Cons: First-pass metabolism = potential (though modest) liver/kidney strain; shorter half-life may demand multiple daily caps.

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Mechanistic Highlights
• Up-regulates mitochondrial genes (PGC-1α, CPT1) ➜ enhanced fat oxidation.
• Improves glucose uptake via GLUT4 translocation — handy in carb refeeds.
• REV-ERBβ binding promotes circadian rhythm alignment and better sleep quality.
• Animal studies showed VO₂ max bumps equivalent to 4–6 weeks of treadmill training.

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“Oral-Only” Performance Stack Ideas
1. SLU-PP-332 + Tadalafil – cardiovascular blood-flow synergy; many users report improved pumps with less systemic fatigue.
2. SLU-PP-332 + L-Carnitine L-Tartrate – doubles down on fatty-acid transport without impacting hormones.
3. SLU-PP-332 + Nootropic Stimulant (e.g., Theacrine) – enhances focus for HIIT sessions when you hate long cardio bouts.
4. Female-Friendly Variant: SLU-PP-332 + Mild Thermogenic (Paraxanthine / Yohimbine combo) — avoids androgenic sides while still leaning out.

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Key Research for Your Rabbit Hole
• PPARδ Activation Drives Endurance Gains in Murine Models
• REV-ERBβ Agonism Enhances Mitochondrial Function and Fat Oxidation
• Exercise-Mimetic Small Molecules: A Comparative Review

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Let’s Hear YOUR Experience
• Have you run SLU-PP-332 orally or pinned?
• Did you keep cardio in or drop it completely?
• What split (frequency / timing) felt best in real life?

Drop your anecdotes below or shoot me a DM if you’d rather chat off-thread!

 

[Bismo]

Not tired or yet but hear mixed reviews. Some say they got terrible headaches. Can’t trust anyone. Could be big pharma trying to scare people off. Peptides are life changers. Millions know this so their bottom line is being affected

 

[aimanabolic]

Not tired or yet but hear mixed reviews. Some say they got terrible headaches. Can’t trust anyone. Could be big pharma trying to scare people off. Peptides are life changers. Millions know this so their bottom line is being affected

I've tested all the way up to 5mg, from 1mg to 5mg I progressively got a wired but tired feeling, and definitely got hotter faster.

1mg has been a sweet spot for myself and a lot of people I know that have taken it, orally anyway.

 

[The_Thannos]

I'm considering this as I still have a good 18lbs of fat to drop just to be "in-shape" (old man issues- and pizza !) is this worth adding? currently on TRT and some Anavar (40/day on cycle)

 

[Bismo]

I'm considering this as I still have a good 18lbs of fat to drop just to be "in-shape" (old man issues- and pizza !) is this worth adding? currently on TRT and some Anavar (40/day on cycle)

I haven’t tried it and know we all lose weight differently but for me, trt and I picked up cycling. Like bike-cycling. I dropped over 50lbs in a year and got a new very addicting hobby. Just checked and in 12 months I’m at 5290 miles of riding, so you know I enjoy it lol Even racing and climbing mountains because I’m not 100% sane. Anavar even at low dose helped me get a few extra tougher pounds off.